Friday, April 26, 2019. (2009) 87:1246–55. doi: 10.1097/TP.0000000000002915, 7. With our expedient, transparent and collaborative peer review, the Nephrology section of Frontiers in Medicine is an ideal outlet for disseminating rapid advances in renal research and for supporting innovations that can drive improve clinical outcomes and direct changes in future clinical practice. Another one is that we are unable to compare the differences in posttransplant kidney function in the four groups i.e., non-Han recipient/Han donor etc. Authors. Front. As for donor-related factors, the recipients receiving a kidney from a younger donor had significantly better impact on kidney function recovery as measured by CysC levels from 1 week to 3 years (P < 0.001) (Figure 4). Kidney transplantation from donors after cardiac death: an initial report of 71 cases from China. Based on these results, it is possible to expand the living donor pool for patients which may reduce waiting time and minimize suffering before transplantation. doi: 10.1097/01.tp.0000228233.09678.22, 9. Black ethnicity is not a risk factor for mortality or graft loss after kidney transplant in the United Kingdom. All of these changes and new developments need to be properly and timely examined, summarized and presented to all stakeholders. Lassus J, Harjola VP. Transplantation. Transpl Int. 50% scientists expect Nephron Journal Impact 2020 will be in the range of 2.5 ~ 3.0. Univariate and multivariate logistic regression analyses were carried out on the study variables, and kidney function of postoperative patients was monitored using cystatin C (CysC) as the outcome indicator. (2011) 365:318–26. Academic Accelerator; Fator de Impacto 2018-19; Frontiers in Medicine; Abreviatura (ISO4) Taxa de aceitação. The results showed that the recipient gender, ethnicity, BMI, and donor age were independent factors affecting postoperative CysC recovery thus reflecting kidney function in renal transplant recipients (P < 0.05). In America, African Americans undergoing deceased donor renal transplantation have lower graft survival compared to Caucasian Americans (15). Transpl Int. To date, numerous studies have demonstrated that many donor- and recipient-related factors are associated with outcomes after kidney transplantation. Exp Clin Transplant. While in China there have been few studies analyzing factors of recipients and donors influencing kidney function after transplantation, and no comparisons among diverse ethnic groups (17–21). Creatinine-based equations for estimation of GFR (eGFR) were established to overcome some of these inadequacies (40). North America . Compared with historical Journal Impact data, the Metric 2019 of Frontiers in Medicine dropped by 11.76%. The antibody response may evolve into acute clinical rejection leading to short-term poor kidney function (36). First, analyzing factors univariately without combination may ignore the interaction and confounding impact on outcomes (11). Similarly, black kidney transplant recipients in the United Kingdom have increased risk of adverse graft-related outcomes owing to high-risk baseline variables (16). More than half of the recipients (51.9%) spent over 1 year on dialysis and the primary method of dialysis was hemodialysis (90.4%). However, some studies have reported an additional 10–20% of living donor procedures were conducted by using ABO incompatible kidney transplantation (37, 38). Front Immunol. Impact Factor 3.9 | CiteScore 4.3 More on impact › ... New advances in medicine and affiliated fields greatly impact the work of clinicians and call for interdisciplinary collaborations, emphasizing the need to remodel preparation programs for graduates in academic nephrology and clinical practice. Kidney transplant graft outcomes in 379 257 recipients on 3 continents. doi: 10.1016/j.transproceed.2013.08.038, 15. The Journal Impact Quartile of Frontiers in Medicine is Q1. (2011) 25:255–64. Ann Intern Med. The aim is to act as a platform for translational research between scientists and clinicians. McGee J, Magnus JH, Islam TM, Jaffe BM, Zhang R, Florman SS, et al. doi: 10.1016/j.transproceed.2012.08.014, 18. doi: 10.1016/j.jnma.2018.10.011, 16. Cohen JB, Owei L, Sawinski DL, Porrett PM. Thirty-five recipients (1.4%) received secondary transplantation and 255 recipients (10.4%) had a history of hepatitis before operation. This study adds to the literature by analyzing a large cohort of recipients in southwestern China. In our study, female recipients had better kidney function than male ones. peter.heeger@mssm.edu South America . doi: 10.3760/cma.j.issn.0376-2491.2017.02.002, 20. A medical graduate of the University of Alabama in Birmingham, he trained in internal medicine and nephrology at the Hospital of the University of Pennsylvania. Based on the multivariate logistic regression analyses, we found that gender, ethnicity, BMI of recipients, and age of donors were independent influence factors. The effect of donor-recipient gender mismatch on short- and long-term graft survival in kidney transplantation: a systematic review and meta-analysis. Frontiers in Medicine - Journal Impact The Journal Impact 2019-2020 of Frontiers in Medicine is 3.000, which is just updated in 2020. An imbalance between the nephron mass of the graft and the recipient's need will impair the prognosis of the organ. Note that 2019 Journal Impact are reported in 2020; they cannot be calculated until all of the 2019 publications have been processed by the indexing agency. The influence of continuous variables such as age on renal function was analyzed by Student's t-test, and categorical variables was analyzed by chi-square test. This difference may be related to the physical constitution and living habits of different ethnic groups, but this hypothesis has yet to be explored. (2017) 8:234. doi: 10.3389/fimmu.2017.00234, 14. 3.900. Am J Transplant. This section provides an Open Access publication forum with rapid turnaround, for high quality research in pulmonary diseases, utilizing an online strategy and efficient review process. Continuous variables were converted into ordinal categorical variables, and the variable with the smallest value was set as a reference. Frontiers journals rank among the world’s most-cited in their fields — including top most-cited in neurosciences, microbiology, plant science and psychology.. Oceania. Comparative analysis of ABO-incompatible living donor kidney transplantation with ABO-compatible grafts: a single-center experience in Korea. It was established in 2007 as Frontiers of Medicine in China, obtaining its current name in 2011. Consistent with our results, several studies in the literature have shown a strong association between age and adverse effect in kidney transplantation (31, 32). 2015(288)]. doi: 10.1111/j.1432-2277.2002.tb00205.x, 28. Not until the matching of the same blood type was unsuccessful, we considered the allocation of different but compatible blood types, that is, the O-type donor to the non-O-type recipient in the next place. More evidence shows that testosterone and estrogens have contrasting effects on chronic allograft nephropathy. However, given the number of patients that were lost to follow-up after 5 years (only 2 patients were followed up for 10 years), the time point of more than 5 years does not appear in the statistical analysis. Compared against mean age of abnormal CysC recipients, the normal CysC recipients mean age was lower. Donors recorded in the Transplant Center Database include immediate or collateral blood-related relative living donors within three generations (n = 1,960), as well as, unrelated donors (n = 497) who were spouse donors (n = 155), a foster father donor (n = 1), and donors after cardiac death (DCD) (n = 341). Updated : May 28, 2020 13:00. Clin Transplant. Authors’ geographical locations. (2015) 68:57–69. Thereafter, even when anti-A/B antibodies recur at high levels they will not harm the kidney transplant, a phenomenon that is called accommodation (13). Additionally, the sample size of each research study has been limited, ranging from 300 to 600 participants (18, 20, 22). Frontiers Editorial Office Avenue du Tribunal Fédéral 34 CH – 1005 Lausanne Switzerland Tel +41(0)21 510 17 40 Fax +41 (0)21 510 17 01, medicine.editorial.office@frontiersin.org, Frontiers Support Tel +41(0)21 510 17 10 Fax +41 (0)21 510 17 01 support@frontiersin.org, Avenue du Tribunal Fédéral 34 CH – 1005 Lausanne Switzerland, Tel +41(0)21 510 17 40 Fax +41 (0)21 510 17 01, For all queries regarding manuscripts in Review and potential conflicts of interest, please contact To gain a better understanding of the impact of donor- and recipient-related factors on kidney transplantation outcomes and to improve donor candidate evaluation and selection before surgery, we incorporated the effect of multiple factors on kidney function after renal transplantation in a larger population of southwestern Chinese people. Donor-related factors of impact on postoperative kidney function reflected by CysC value: Comparison of the age of donors with normal and abnormal CysC at different time points follow up after surgery (**P < 0.001). doi: 10.1172/JCI103085, 13. Dongping G, Yang L, Xiaobei S, Junxiang X, Yuan Y, Hui C. Long-term factors influencing survival after kidney transplantation. 2015(288)] before subjects participation in the study. 7:519582. doi: 10.3389/fmed.2020.519582. Frontiers in Molecular Medicine is a peer-reviewed, open access journal that publishes novel findings that elucidate disease pathogenesis at the molecular or physiological level, which may lead to the design of specific tools for diagnosis, treatment, or prevention of diseases. Prognostic significance of serum cystatin c concentrations in renal transplant recipients: 5-year follow-up. (2002) 15:494–501. (2013) 27:764–71. Risk factors for delayed graft function after renal transplantation and their significance for long-term clinical outcome. Opposite effects of testosterone and estrogens on chronic allograft nephropathy. Transplantation kidney function recovery in non-Han vs. Han Chinese individuals has not previously been investigated in China, but our results show that non-Han recipients have a better graft condition after kidney transplantation than Han recipients. CysC, a cysteine protease inhibitor, possesses many attributes required for the ideal eGFR marker. Improving utilization of deceased donor kidneys by matching recipient and graft survival. All of these changes and new developments need to be properly and timely examined, summarized and presented to all stakeholders. Our analytic cohort is kidney transplant patients receiving allogeneic kidney transplantation in the Transplant Center Database of West China Hospital of Sichuan University from June 2003 to January 10, 2018 (N = 3,067). For these reasons, graft rejection or chronic allograft dysfunction is usually discovered too late to adjust therapeutic measures (15). ABO incompatible renal transplantation: a paradigm ready for broad implementation. Background: Factors influencing the kidney function of patients after renal transplantation include both recipient-related factors and donor-related factors. J Am Coll Surg. The full analytic cohort contained 2,462 transplant recipients from December 13, 2008 to January 10, 2018. Cippà PE, Schiesser M, Ekberg H, van Gelder T, Mueller NJ, Cao CA, et al. Risk factors for acute rejection after deceased donor kidney transplantation in China. Smaller BMI recipients had larger percentage of normal CysC. Frontiers in Cellular and Infection Microbiology. Frontiers in Medicine publishes rigorously peer-reviewed research linking basic research to clinical practice and patient care, as well as translating scientific advances into new therapies and diagnostic tools. Asia. A higher BMI means greater demand on the kidney, that is, female recipients need fewer nephrons leading to a better outcome. Opelz G, Döhler B. Journal Impact Prediction System displays the exact community-driven Metric without secret algorithms, hidden factors… Female gender was a protective factor for CysC recovery from 1 day to 2 years (P < 0.05, OR <1), and non-Han minority was a protective factor from 1 week to 3 months (P < 0.05, OR <1). Adv Clin Chem. Antus B, Yao Y, Song E, Liu S, Lutz J, Heemann U. doi: 10.1097/00007890-200201150-00013, 29. This is consistent with earlier studies (20, 33) and has great clinical value. Additionally, the frequency of blood group O significantly increased in the donor population compared with the recipients in our study. The temporal and long-term impact of donor body mass index on recipient outcomes after kidney transplantation - a retrospective study. Higgins RM, Daga S, Mitchell DA. Kidney Int. Risk stratification for rejection and infection after kidney transplantation. Transplantation. The impact factor (IF) 2018 of Frontiers in Medicine is 3.00, which is computed in 2019 as per it's definition. Citations (Crossref total) Articles published (total) Articles published (cumulative per year) Article views & downloads (total) Sections (total) Editors (total) Top Institutions. Besides, there are many potential differences between diverse population such as socioeconomics, pharmacogenomics, social systems, access to care that may explain the disparate outcomes (25). Frontiers in Medicine Impact Factor 2018-2019. All data are anonymous to protect patient privacy. As an open access journal, Frontiers in Medicine is committed to empowering researchers and practitioners by providing an open and transparent resource to publish the latest breakthroughs in nephrology. Gender compatible recipients with donors had higher CysC normal percentage from 1 month to 4 years, except at 2 years (P < 0.05) (Figure 3). Come learn how science and technology are helping us stay healthy, sharp, and connected well into old age—and how our longer, livelier lifespans will shape society. A systematic analysis of worldwide population-based data on the global burden of chronic kidney disease in 2010. The outcomes have improved dramatically with the development of matching rules. A contemporary analysis of outcomes and modifiable risk factors of ethnic disparities in kidney transplantation. Am J Transplant. As a result, in addition to increasing the quantity of kidney transplant procedures, improving the long-term survival rate of recipients and ensuring the quality of renal function after transplantation have become primary objectives for all transplant centers. This retrospective study incorporated 2,462 individuals undergoing renal transplantation during the last decade in southwestern China. From the univariate analyses, we observed that recipient-related factors such as age, ethnicity, BMI, and HLA loci mismatch were related to short-term influence on kidney function after renal transplantation; specifically, the gender of recipients as well as gender-consistency were strongly associated with both short-term and long-term postoperative kidney function. Publication type: Journals: ISSN: 16643224: Coverage: 2010-2020: Scope: Frontiers in Immunology is a leading journal in its field, publishing rigorously peer-reviewed research across basic, translational and clinical immunology. Nephrology welcomes submissions of the following article types: Brief Research Report, Case Report, Clinical Trial, Correction, Editorial, General Commentary, Hypothesis and Theory, Methods, Mini Review, Opinion, Original Research, Perspective, Review, Study Protocol and Systematic Review. Europe. (2019) 20:409. doi: 10.1186/s12882-019-1557-x, 23. Owing to its growing population, China has the second highest incidence of kidney transplants in the world, after the United States. Among the immune-independent factors is a possible role for inadequate nephron dosing leading to glomerular hyperfiltration and progressive graft damage (29). Heldal K, Hartmann A, Leivestad T, Foss A, Midtvedt K. Risk variables associated with the outcome of kidney recipients >70 years of age in the new millennium. Multi-center data analysis would be an optimal next step to confirm the results. ABO-incompatible kidney transplantation. 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